Methylthioadenosine (MeSAdo) Phosphorylase Deficiency in Malignancy
The abnormal growth properties of cancer cells must be mediated finally by changes in specific metabolic pathways. In general, malignant transformation is associated with an increase in the activities of enzymes involved in DNA, RNA, and protein synthesis, and a concomitant decrease in the activities of enzymes that degrade cellular metabolites. However, no specific metabolic pathway has been found that distinguishes normal from malignant cells, or is common to all tumors.
KeywordsOrnithine Decarboxylase Diphtheria Toxin Polyamine Metabolism Polyamine Synthesis Specific Metabolic Pathway
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- 10.A. E. Pegg, and P. P. McCann, Polyamine metabolism and function, Am.J.Phvsiol. 243: C212 (1982).Google Scholar