Androgen Regulation of Ornithine Decarboxylase and S-Adenosylmethionine Decarboxylase Gene Expression

  • Olli A. Jänne
  • Anne Crozat
  • Mervi Julkunen
  • Noreen J. Hickok
  • Leonard Eisenberg
  • Evie Melanitou
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 250)


The action of androgenic steroids in their target tissues occurs in a receptor-mediated fashion similar to that of other steroid hormones (1–3). Over the last several years, a number of gene products regulated by androgens have been characterized and their induction kinetics in vivo elucidated. The best defined genes fall, with regard to the tissues of their expression, into three main categories: (i) α2u-globulin and the major urinary protein genes are regulated by androgens in rodent liver; (ii) prostatein and seminal vesicle basic protein genes are controlled by androgens in rat accessory sex organs; and (iii) ornithine decarboxylase, β-glucuronidase, RP2, and kidney androgen-regulated protein genes exhibit androgen regulation in murine kidney.


Ornithine Decarboxylase Mouse Kidney mRNA Accumulation Murine Kidney Androgen Regulation 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Olli A. Jänne
    • 1
  • Anne Crozat
    • 1
  • Mervi Julkunen
    • 1
  • Noreen J. Hickok
    • 1
  • Leonard Eisenberg
    • 1
  • Evie Melanitou
    • 1
  1. 1.The Population CouncilThe Rockefeller UniversityNew YorkUSA

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