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Interspecies Extrapolation

  • Curtis C. Travis

Abstract

One of the fundamental problems in the cancer risk assessment area is the extrapolation of observed experimental results between animal species and man. Lacking detailed information on interspecies differences, it is frequently assumed that experimental results can be extrapolated between species when administered dosage is standardized as either mg/kg body weight per day (body weight scaling) or mg/m2 per day (surface area scaling). Several investigators have argued for the efficacy of one or the other of these procedures (Pinkel, 1958; Freireich et al., 1966; Crouch and Wilson, 1978; Hoel, 1979; Crump and Guess, 1980; Hogan and Hoel, 1982; MRI, 1986; FASEB, 1986; Travis and White, 1988). It is well recognized that neither of these extrapolation procedures will be exactly correct for all compounds and that when species-specific data are available, they should be used in risk assessment. In their absence, body weight or surface area extrapolations are used with the explicit knowledge that they are only approximately correct.

Keywords

Partition Coefficient National Research Council Pharmacokinetic Model Intravenous Dose Reactive Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Curtis C. Travis
    • 1
  1. 1.Office of Risk AnalysisOak Ridge National LaboratoryOak RidgeUSA

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