Pathogenic Interrelationship of Focal Lesions, Nodules, Adenomas and Carcinomas in the Multistage Evolution of Azaserine-Induced Rat Pancreas Carcinogenesis
It is widely accepted now that cancer develops in a cellular multistage proces in which cell populations of increasing neoplastic potential develop in a stochastic (and probably clonal) way from less neoplastic precursor cell populations. The increasing malignancy of tumors in time (progression, Foulds ) has since long been explained in this way, but recent results from i.a. rat hepatocarcinogenesis (Scherer ) and mouse skin carcinogenesis (Hennings and Yuspa ) indicate that a similar stochastic process operates in the development of the tumor from initiated cell clones and intermediate neoplastic cell populations (promotion).
KeywordsAcinar Cell Pancreatic Carcinogenesis Acinar Tissue ATPase Staining Precursor Cell Population
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