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Pathogenic Interrelationship of Focal Lesions, Nodules, Adenomas and Carcinomas in the Multistage Evolution of Azaserine-Induced Rat Pancreas Carcinogenesis

  • E. Scherer
  • J. Bax
  • R. A. Woutersen

Abstract

It is widely accepted now that cancer develops in a cellular multistage proces in which cell populations of increasing neoplastic potential develop in a stochastic (and probably clonal) way from less neoplastic precursor cell populations. The increasing malignancy of tumors in time (progression, Foulds [1969]) has since long been explained in this way, but recent results from i.a. rat hepatocarcinogenesis (Scherer [1987]) and mouse skin carcinogenesis (Hennings and Yuspa [1985]) indicate that a similar stochastic process operates in the development of the tumor from initiated cell clones and intermediate neoplastic cell populations (promotion).

Keywords

Acinar Cell Pancreatic Carcinogenesis Acinar Tissue ATPase Staining Precursor Cell Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • E. Scherer
    • 1
  • J. Bax
    • 1
  • R. A. Woutersen
    • 2
  1. 1.Division of Chemical CarcinogenesisThe Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis)AmsterdamThe Netherlands
  2. 2.Department of Biological ToxicologyTNO-CIVO Toxicology and Nutrition InstituteZeistThe Netherlands

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