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Biologically Based Methods for Cancer Risk Assessment pp 319–338Cite as

Determination of Carcinogen Exposure by Immunological Techniques

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Abstract

Humans are exposed to carcinogens from a variety of sources including food, drinking water, air, and the working environment. A few of these carcinogens have been identified epidemiologically, but the majority have been identified by animal bioassays and their impact on human cancer is not well established. The mathematical quantitation of human cancer risk from exposures to animal carcinogens relies on the validity of animal to man extrapolations. Several pieces of information could increase the validity of such extrapolations. Among these, comparative pharmacokinetic data from the relevant test animals and from man are particularly important because these data will tell to what extent the compound is handled similarly and whether it elicits toxicity by the same mechanism in the two species. The quantitation of human risk is also highly dependent on data providing the actual human exposure levels. Futhermore, large interindividual variations in exposures and in pharmacokinetics are most probably found for most carcinogens in human populations. Therefore this variability should also be validated in order not to underestimate the risk to certain groups or individuals.

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Authors and Affiliations

  1. Department of Biochemical and Molecular Toxicology, National Food Agency of Denmark, Institute of Toxicology, 19 Mørkhøj Bygade, Dk-2860, Søborg, Denmark

    Lars O. Dragsted

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  1. Lars O. Dragsted
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  1. Office of Risk Analysis, Oak Ridge National Laboratory, 37831-6109, Oak Ridge, Tennessee, USA

    Curtis C. Travis

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© 1989 Plenum Press, New York

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Dragsted, L.O. (1989). Determination of Carcinogen Exposure by Immunological Techniques. In: Travis, C.C. (eds) Biologically Based Methods for Cancer Risk Assessment. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5625-7_23

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  • DOI: https://doi.org/10.1007/978-1-4684-5625-7_23

  • Publisher Name: Springer, Boston, MA

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