Multistage Models for Cancer Risk Assessment
A biologically realistic quantitative model of carcinogenesis is one component of a scientific approach to cancer risk assessment. The parameters of such a model should have clear interpretation in biological terms and, if their dependence on dose of environmental agent can be measured or inferred, then the model can be used for low-dose and inter-species extrapolation of cancer risk.
KeywordsMutation Rate Hazard Function Intermediate Cell Cancer Risk Assessment Sodium Saccharin
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