The Use of ALDH Induction as a Carcinogenic Risk Marker in Comparison with Typical in Vitro Mutagenicity System
Several aldehyde-oxidizing isozymes, the aldehyde dehydrogenases (ALDHs), are distributed in the mitochondrial, the microsomal and the cytosolic fraction of the rat liver (Deitrich, 1966; Tottmar et al., 1973). Previous studies have described the induction of two cytosolic aldehyde dehydrogenases by a variety of xenobiotics (Deitrich, 1971; Deitrich et al., 1977). Phenobarbital induces a specific ALDH (PB-ALDH) in certain genetically defined rat strains (Deitrich, 1971; Marselos, 1976). In addition, another cytosolic ALDH (T-ALDH) is induced by 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD) and certain carcinogenic polycyclic aromatic hydrocarbons (P.A.Hs) in all rat strains tested (Marselos and Hanninen, 1974; Deitrich et al., 1978; Marselos et al., 1979). This isozyme is induced also in cultures of human hepatocytes, after in vitro exposure to 3-methylcholanthrene (Marselos et al., 1987).
KeywordsPolycyclic Aromatic Hydrocarbon Aldehyde Dehydrogenase ALDH Activity Carcinogenic Potency Aldehyde Dehydrogenase Activity
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