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The Role of Inhibited Intercellular Communication in Carcinogenesis: Implications for Risk Assessment from Exposure to Chemicals

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Book cover Biologically Based Methods for Cancer Risk Assessment

Abstract

With the reality that humans cannot live without chemicals and that the number of new chemicals to which we are exposed is increasing, the justified concern over the potential harm of any one or mixture of these chemicals to human health is also growing every day (Steering Committee, 1984). In addition, the harsh reality is that these chemicals cannot all be tested, in an absolute fashion, for their potential toxicity as an acute toxicant, teratogen, carcinogen, neuro-or reproductive toxicant. Constraints, such as (a) our lack of basic understanding of the mechanisms by which chemicals might lead to various toxic endpoints; (b) the reliance on short-term assays and animal model surrogates for human exposure; (c) limited resources (human, financial, technical) to perform the toxicological tests; and (d) imprecise ability due to species, genetic, developmental stage, sex and nutritional/occupational/environmental background, to extrapolate from short-term test or animal bioassay results to the unique individual human situation, put great uncertainties in any risk assessment process.

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  1. Michigan State University, East Lansing, Michigan, 48824, USA

    J. E. Trosko & C. C. Chang

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  1. J. E. Trosko
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  1. Office of Risk Analysis, Oak Ridge National Laboratory, 37831-6109, Oak Ridge, Tennessee, USA

    Curtis C. Travis

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Trosko, J.E., Chang, C.C. (1989). The Role of Inhibited Intercellular Communication in Carcinogenesis: Implications for Risk Assessment from Exposure to Chemicals. In: Travis, C.C. (eds) Biologically Based Methods for Cancer Risk Assessment. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5625-7_13

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