Dose Fractionation in Neutron Capture Therapy for Malignant Melanoma
Australia is entering a joint clinical trial with Japan for thermal Neutron Capture Therapy of selected patients with superficial local recurrent, local advanced and isolated metastatic malignant melanoma. The para-boronophenylalanine (BPA) compound will be used with a neutron fluence of about 1013 neutrons per cm2, to be delivered in a single dose. While in the initial trials of NCT, the single dose is a practical procedure, there may be advantages in dose fractionation, and these are considered in this paper.
KeywordsBoron Atom Hypoxic Cell Boron Neutron Capture Therapy Dose Fraction Neutron Radiography
Unable to display preview. Download preview PDF.
- 1.Proceedings of the Second Japan-Australia Workshop on Neutron Capture Therapy for Malignant Melanoma, to be published in Pigment Cell Research, 1988.Google Scholar
- 2.D. Barkla, B. J. Allen, J. K. Brown, and M. M. Mountford, Ref. 1.Google Scholar
- 3.Z. A. Abdel Malek, K. L. Kreutzfeld, M. M. Marwan, M. E. Hadley, V. J. Hruby, and B. C. Wilkes, Prolonged stimulation of 591 melanoma tyrosinase by [Nle4,D-Phi7] - substituted a - melanotropins. Cancer Res. 45: 4735 (1985).Google Scholar
- 4.M. L. Steinberg, and J. R. Whittaker, Stimulation of mela- notic expression in a melanoma cell line by theophylline. J. Cell. Physiol . 87: 265 (1976).Google Scholar
- 8.P. Hersey, Preclinical and phase I studies of monoclonal antibodies in melanoma - application to boron neutron capture therapy of melanoma, Ref. 1.Google Scholar
- 10.E. J. Hall, “Chemical and Pharmacological Modifiers, Radiobiology for the Radiologist,” Harper & Row Publishers, Inc., N.Y. (1978).Google Scholar
- 11.Y. Mishima, M. Ichihashi, M. Tsuji, M. Ueda, S. Hatta, T. Nakagawa, C. Tanaka, K. Taniyama, T. Suzuki, Prerequisites of first clinical trial for melanoma selective thermal neutron capture therapy, Neutron Capture Therapy Proc. Second Int. Sym., Tokyo, October, 1985, ed., H. Hatanaka, Nishimura, 230 (1986).Google Scholar