Fractionation in Boron Neutron Capture Therapy
The theoretical basis has been described for the value of BNCT in the treatment of cerebral glioblastoma multiforme.1 Early clinical trials in the United States showed unexpected and excessive damage to normal brain tissue. Subsequent analysis suggests that this damage was due to high levels of boron in blood at the time of irradiation. After modification of the technique, Hatanaka2 demonstrated that the method is effective, with 30% of the patients in his study surviving five years. This is a striking result in the treatment of a tumor, where a 95% two-year mortality and 100% five-year mortality can be expected after treatment by conventional photon radiation therapy.3 It also is clear that some patients tolerated the treatment without gross intellectual damage, although data on normal tissue damage in this series is incomplete.
KeywordsNeutron Beam Late Toxicity Boron Neutron Capture Therapy Relative Biological Effectiveness Boron Compound
Unable to display preview. Download preview PDF.
- 1.R. G. Zamenhof, B. W. Murray, G. L. Brownell, G. R. Wellum, and E. I. Tolpin, Boron neutron therapy for the treatment of cerebral gliomas, Med. Phys. 2: 47 (1975).Google Scholar
- 2.H. Hatanaka, K. Amano, S. Kamano, and K. Sano, Clinical experience of boron neutron capture therapy for malignant brain tumors (1968–1985), in: “Neutron Capture Therapy,” H. Hatanaka, ed., Nishimura, Tokyo (1986).Google Scholar
- 4.M. Strandquist, Studien ube die Kumulative Wirkung der Roentgenstrahlen bei Fraktionierung. Acta Radiol. (Suppl) 55: 1 (1944).Google Scholar
- 5.M. M. Elkind, H. Sutton-Gilbert, W. B. Moses, T. Alescio, and R. W. Swain, Radiation response of mammalian cells in culture, Radiat. Res. 25: 359 (1965)Google Scholar
- 7.J. W. Hopewell, D. W. H. Barnes, M. E. C. Robbins, J. M.Samson, J. T. Knowles, and G. J. M. J. van den Aardwig, The relative biological effectiveness of fractionated doses of fast neutrons for normal tissues in the pig. Brit. J. Radiol. (in press).Google Scholar
- 9.B. J. Allen, J. K. Brown, and B. Harrington, Neutron capture therapy research for malignant melanoma, in: “Neutron Capture Therapy,” H. Hatanaka, ed., Nishimura, Tokyo (1986).Google Scholar