BNCT Project in Czechoslovakia

  • J. Burian
  • I. Janku
  • J. Kvitek
  • V. Mares
  • Z. Prouza
  • F. Spurny
  • K. Sourek
  • B. Stibr
  • O. Strouf
Part of the Basic Life Sciences book series (BLSC, volume 50)


In Czechoslovakia, a multidisciplinary research group for BNCT of human brain gliomas has been constituted in 1980. Mercaptoborane compound has been synthesized suitable for clinical use. The configuration of a thermal neutron beam with appropriate parameters has been created using the 10 MW VVR-S research reactor and proved experimentally. The realization of a technical project for a clinical pilot study could be expected by 1992. The project has been sponsored by the Czechoslovak Academy of Sciences and Faculty of Medicine, Charles University in Prague.


Malignant Glioma Thermal Neutron Boron Neutron Capture Therapy Thermal Neutron Flux Neutron Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    H. Hatanaka and W. H. Sweet, Slow-neutron capture therapy for malignant tumours. Its history and recent development. in: Biomedical Dosimetry, International Atomic Energy Agency, 147–178, Vienna (1975).Google Scholar
  2. 2.
    F. Tovarys, Lecba mozkovych nadoru zachytem tepelnych neutronu na boru. Cas. Lek. ces., 29: 118 (1979).Google Scholar
  3. 3.
    M. Komura, K. Aono, K. Nagasawa, and S. Sumimoto, Chem. Express 2: 173 (1987).Google Scholar
  4. 4.
    B. Casensky and J. Machacek, Czech. Pat. 187046.Google Scholar
  5. 5.
    J. Plesek, B. Stibr, E. Drdakova, and T. Jelinek, Czech. Pat. Appl. PV 8695–84.Google Scholar
  6. 6.
    J. Plesek, B. Stibr, and E. Drdakova, Czech. Pat. 238254.Google Scholar
  7. 7.
    E. I. Tolpin, G. R. Wellum, and S. A. Perley, Synthesis and chemistry of mercaptoundecahydro-closo-dodecaborate (2-), Inorg. Chem. 17: 2867 (1978).CrossRefGoogle Scholar
  8. 8.
    J. Plesek, T. Jelinek, E. Drdakova, S. Hermanek, and B. Stibr, A convenient preparation of 1-CB11H-12 and its C-amino derivatives, Collect. Czech. Chem. Commun. 49: 1559 (1984).CrossRefGoogle Scholar
  9. 9.
    J. Plesek, T. Jelinek, and B. Stibr, Unusual demethylation of 1-dimethylamine-l-carba-closo-dodecaborane (11), Polyhedron 3: 1351 (1984).CrossRefGoogle Scholar
  10. 10.
    T. Jelinek, J. Plesek, S. Hermanek, and B. Stibr, Chemistry of compounds with the 1-carba-closo-dodecaborane (12) framework, Collect. Czech. Chem. Commun. 51: 819 (1986).CrossRefGoogle Scholar
  11. 11.
    A. H. Soloway and J. R. Messer, Anal. Chem. 36: 433 (1964).CrossRefGoogle Scholar
  12. 12.
    A. Kaczmarczyk, J.R. Messer, and C. E. Pierce, Rapid method for determination of boron in biological materials, Anal. Chem. 43: 271 (1971).PubMedCrossRefGoogle Scholar
  13. 13.
    J. Cervena, V. Hnatowicz, J. Hoffman, Z. Kosina, J. Kvitek, and P. Onheiser, The use of neutron induced reaction for boron profiling in Si, Nucl. Instr. and Meth. 188: 185 (1981).CrossRefGoogle Scholar
  14. 14.
    V. Mares, M. Baudysova, J. Kvitek, J. Sykorova, J. Cervena, J. Vacik, V. Hnatowicz, and Z. Kunc, Uptake of Na2B12H11SH in cell lines and human biopsies. in: “Molecular Basis of Neural Function,” S. Tucek et al., eds., E.S.N., Prague, 1978.Google Scholar
  15. 15.
    V. Mares, J. Burian, M. Baudysova, Z. Prouza, and Z. Kunc, Interaction of thermal neutrons and boron-10 in the immature brain, Physiol. Bohemoslov. 36: 545 (1987).Google Scholar
  16. 16.
    M. Baudysova, V. Mares, J. Kvitek, J. Cervena, J. Vacik, V. Hnatowicz, and Z. Kunc, Incorporation of Na210B12H11SH2used for boron neutron capture therapy into tumor-derived and normal cells, Physiol. Bohemoslov. (in press).Google Scholar
  17. 17.
    Z. Prouza, D. Nikodemova, A. Hrabovcova, J. Kubeckova, H. Solnicka, Jaderna energie 24:6,213 (1978) (Engl.)Google Scholar
  18. 18.
    F. Spurny, R. Medioni, G. Pescayre, and G. Portal, Proc. 3rd Symv. Neutron Dosimetry in Biology and Medicine. Neuherherg. 977. EUR 5848 DE/EN/FR, Luxembourg, 77 (1978) (Engl.).Google Scholar
  19. 19.
    A. Skubal, Z. Prouza, J. Hermanska, Energy and kerma dependence of the Czechoslovak dosimetric Si-diode, Jaderna energie 31:10,371 (1985) (Engl.).Google Scholar
  20. 20.
    J. Hermanska, Z. Prouza, M. Karny, and I. Nemec, Bayes-based dose equivalent estimation using multisphere data, Kernenenergie 30: 10, 409 (1987).Google Scholar
  21. 21.
    F. Spurny and I. Votockova, Proc. 4th Symp. Neutron Dosimetry.Neuherberg. 1981. EUR 7448 EN. Luxembourg, 327 (1981) (Engl.).Google Scholar
  22. 22.
    J. Huylka, Z. Hrdlicka, Z. Janout, S. Pospisil, Z. Kansky, and Z. Prouza, Merenidistribuce hustolg tokutepelnych neutroni v objektu, modeljicim lidske telo, ponoce polovodicoveho kremikoveho detektoru S 6Li-konvertorem, Jaderna energie 31: 10, 376 (1985).Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • J. Burian
    • 1
  • I. Janku
    • 2
  • J. Kvitek
    • 3
  • V. Mares
    • 4
  • Z. Prouza
    • 5
  • F. Spurny
    • 6
  • K. Sourek
    • 7
  • B. Stibr
    • 8
  • O. Strouf
    • 8
  1. 1.Institute of Nuclear ResesarchCzechoslovak Atomic AgencyPragueCzech Republic
  2. 2.Institute of PharmacologyCzechoslovak Academy of SciencesPragueCzech Republic
  3. 3.Institute of Nuclear PhysicsCzechoslovak Academy of SciencesPragueCzech Republic
  4. 4.Institute of PhysiologyCzechoslovak Academy of SciencesPragueCzech Republic
  5. 5.Institute of Biophysics and Nuclear Medicine, Faculty of MedicineCharles UniversityPragueCzech Republic
  6. 6.Institute of Radiation DosimetryCzechoslovak Academy of SciencesPragueCzech Republic
  7. 7.Neurosurgical Clinic, Faculty of MedicineCharles UniversityPragueCzech Republic
  8. 8.Institute of Inorganic ChemistryCzechoslovak Academy of SciencesPragueCzech Republic

Personalised recommendations