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Toxicities of Na2B12H11SH and Na4B24H22S2 in Mice

  • Paul G. Marshall
  • Marilyn E. Miller
  • Stanley Grand
  • Peggy L. Micca
  • Daniel N. Slatkin
Part of the Basic Life Sciences book series (BLSC, volume 50)

Abstract

The sodium salt of the anionic icosahedral borane (B12H11SH2−)1,2 is used clinically in Japan3,4 as a 10B transport agent for boron neutron capture therapy [BNCT] of brain tumors. Although the dimer of that borane has greater affinity to a transplanted murine melanoma and to a transplanted rat glioma than does the parent monomer, the toxicity of the dimer has been cited5 as a factor that might limit its usefulness for BNCT clinically. Thus, it was considered appropriate to assess the relative severity of the toxic effects of the monomer and the dimer in mice.

Keywords

Abdominal Incision Boron Neutron Capture Therapy Brookhaven National Laboratory Osmotic Pump Blood Hemoglobin Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Paul G. Marshall
    • 1
  • Marilyn E. Miller
    • 1
  • Stanley Grand
    • 1
    • 2
  • Peggy L. Micca
    • 1
    • 3
  • Daniel N. Slatkin
    • 1
    • 3
  1. 1.Division of Hematological ResearchMemorial HospitalPawtucketUSA
  2. 2.Department of PathologyJohn T. Mather Memorial HospitalPort JeffersonUSA
  3. 3.Medical DepartmentBrookhaven National LaboratoryUptonUSA

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