Toxicities of Na2B12H11SH and Na4B24H22S2 in Mice
The sodium salt of the anionic icosahedral borane (B12H11SH2−)1,2 is used clinically in Japan3,4 as a 10B transport agent for boron neutron capture therapy [BNCT] of brain tumors. Although the dimer of that borane has greater affinity to a transplanted murine melanoma and to a transplanted rat glioma than does the parent monomer, the toxicity of the dimer has been cited5 as a factor that might limit its usefulness for BNCT clinically. Thus, it was considered appropriate to assess the relative severity of the toxic effects of the monomer and the dimer in mice.
KeywordsAbdominal Incision Boron Neutron Capture Therapy Brookhaven National Laboratory Osmotic Pump Blood Hemoglobin Concentration
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