Uptake of Boron into Human Gliomas of Athymic Mice and into Syngeneic Cerebral Gliomas of Rats after Intracarotid Infusion of Sulfhydryl Boranes
Effective boron neutron capture therapy (BNCT) of brain tumor will be dependent upon the use of boron-transport agents that give adequate levels of 10B in tumor tissue but low boron concentrations in blood and normal brain.1 Several 10B-transport agents are being studied in animals, however, only the sulfhydryl borane monomer (Na2B12H11SH) is currently used (in Japan) for the treatment of human malignant gliomas.2 Our studies show that after the administration of the sulfhydryl borane dimer (Na4B24H22S2) tumor boron concentrations are significantly higher than those obtained following the administration of equal amounts of boron as monomer.3,4 This report presents preliminary results on: a) the uptake of monomer and dimer in tumors arising from a human malignant glioma-derived cell line inoculated subcutaneously in athymic (nude) mice; and b) the comparison of intracarotid and intravenous infusion of monomer and dimer on the resultant boron concentrations in cerebral gliomas of rats.
KeywordsHuman Glioma Boron Concentration Subcutaneous Tumor Boron Neutron Capture Therapy Athymic Mouse
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