Implications of Genotypic and Microenvironmental Heterogeneity for the Cure of Solid Tumors by Neutron Capture Therapy

  • Sara Rockwell
Part of the Basic Life Sciences book series (BLSC, volume 50)


There is increasing evidence for genotypic, phenotypic, and microenvironmental heterogeneity within solid tumors in experimental animals and in humans. This heterogeneity influences the response of the tumors to treatment with radiation, cytotoxic drugs, hyperthermia, and immunotherapy, and may also influence the efficacy of neutron capture therapy. This paper reviews the data on heterogeneity in solid tumors and considers the implications of these data for curative NCT.


Mouse Mammary Tumor Virus Hypoxic Cell Pyridine Nucleotide Human Tumour Xenograft Perfusion Deficit 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Sara Rockwell
    • 1
  1. 1.Department of Therapeutic RadiologyYale University School of MedicineNew HavenUSA

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