Neutron Capture Therapy in Support of Other Radiation Treatment
Neutron capture therapy (NCT) appears potentially useful, not only as a treatment modality per se, but also as an adjuvant in the context of established clinical measures to control pathological growth. Since the probability of local control is a steep function of absorbed dose, even a modest specific exposure of neoplasms by such techniques would significantly increase the chances of cure. Such a prospect seems most natural in fast neutron therapy 1,2,3 where slow neutrons are automatically available in the target area. As a promising alternative, it would be possible to combine the use of protons or heavier ions with a booster therapy based on boron compounds and intermediate-energy neutrons.4 Such a situation would be particularly relevant when there are needs both for the precision of heavy charged-particle beams--permitting tailored 3-dimensional dose plans for the treatment of structures visible by computerized imaging methods--and for the particular features of NCT that also aim at eradication of invisible but suspected microsopic growth in larger anatomical regions.
KeywordsNeutron Capture Boron Concentration Relative Biological Effectiveness Tumor Spheroid Boron Compound
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