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Selective Thermal Neutron Capture Therapy and Diagnosis of Malignant Melanoma: From Basic Studies to First Clinical Treatment

  • Yutaka Mishima
  • Masamitsu Ichihashi
  • Susumu Hatta
  • Chihiro Honda
  • Akihiro Sasase
  • Keizo Yamamura
  • Keiji Kanda
  • Tooru Kobayashi
  • Hiroshi Fukuda
Part of the Basic Life Sciences book series (BLSC, volume 50)

Abstract

As melanoma genesis occurs in pigment cells, accentuated melanogenesis concurrently occurs in principlel. Thus, harnessing this accentuation of melanogenesis, we developed a new mutually-dependent two-step therapy, in which melanogenesis-seeking compounds first specifically target melanoma cells, enabling the powerful second step to selectively destroy the targeted cells. Our new thermal neutron capture therapy2,3,4,5(NCT) uses a 10B-dopa(melanin substrate) analogue, 10B1-p-boronophenylalanine (10B1-BPA) which accumulates preferentially in melanoma cells6,7. The cells then are irradiated with thermal neutrons to induce the 10B(n, α)7Li reaction which releases energy of 2.33MeV to a distance of 10~14μ, the diameter of melanoma cells. Extensive in vitro and in vivo radiobiological analysis8 confirmed the highly enhanced killing effect of 10B1-BPA. Measurements of the accumulating capacity of 10B1-BPA into melanoma cells in vitro and in vivo using both chemical and prompt gamma ray spectrometry7 assay showed its high affinity for these cells9.

Keywords

Thermal Neutron Relative Biological Effectiveness Thermal Neutron Capture Melanoma Lesion Clinical Dosimetry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Yutaka Mishima
    • 1
  • Masamitsu Ichihashi
    • 1
  • Susumu Hatta
    • 1
  • Chihiro Honda
    • 1
  • Akihiro Sasase
    • 1
  • Keizo Yamamura
    • 1
  • Keiji Kanda
    • 2
  • Tooru Kobayashi
    • 2
  • Hiroshi Fukuda
    • 3
  1. 1.Department of Dermatology Special Institute of Cancer Neutron Capture TherapyKobe University School of MedicineKobe, 650Japan
  2. 2.Research Reactor InstituteKyoto UniversityOsakaJapan
  3. 3.National Institute of Radiological SciencesChiba, 260Japan

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