Tumor-Seeking Compounds for Boron Neutron Capture Therapy: Synthesis and Biodistribution

  • Detlef Gabel
Part of the Basic Life Sciences book series (BLSC, volume 50)


A successful application of boron neutron capture therapy towards the treatment of human malignancies relies on two prime conditions: the delivery of a sufficient amount of neutrons to the target volume, and the delivery of a sufficient amount of boron to the target cells.


Neutron Capture Boron Concentration Boron Neutron Capture Therapy Cellulose Nitrate North Atlantic Treaty Organization 
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  1. Allen, B.J., Brown, J.K., Harrington, B., Izard, B., Linklater, H., Maddalena, D.J., McNeill, J., McGregor, M.J., Mountford, M.H., Snowdon, G.M., Wilson, D.J., Wilson, J.G., Parsons, P., Moore, D., Tamat, S., and Hersey, P., 1986, Neutron capture therapy research for malignant melanoma, in “Neutron Capture Therapy”, H. Hatanaka, ed., Nishimura, Niigata.Google Scholar
  2. Demers, D.R., and Allemand, C.D., 1981, Atomic fluorescence spectrometry with an inductively coupled plasma as atomization cell and pulsed hollow cathode lamps for excitation, Anal. Chem. 53: 1915.CrossRefGoogle Scholar
  3. Fairchild, R.G., Packer, S., Greenberg, D., Som, P., Brill, A.B., Fand, I., and McNally, W.P., 1982, Thiouracil distribution in mice carrying transplantable melanoma, Cancer Res. 42: 5126.PubMedGoogle Scholar
  4. Fairchild, R.G., Gabel, D., Hillman, M., and Watts, K., 1984, The distribution of exogenous porphyrins in vivo; implications for neutron capture therapy, in “Proceedings of the First International Symposium on Neutron Capture Therapy”, R.G. Fairchild and G.L. Brownell, eds., BNL Report 51730, Upton, N.Y.Google Scholar
  5. Gabel, D., Foster, S., and Fairchild, R.G., 1987a, The Monte Carlo simulation of the biological effect of the 10B(n,a)7Li reaction in cells and tissue and its implication for boron neutron capture therapy, Radiat. Res. 111: 14.PubMedCrossRefGoogle Scholar
  6. Gabel, D., Holstein, H., Larsson, B., Gille, L., Ericson, G., Sacker, D., Som, P., and Fairchild, R.G., 1987b, Quantitative neutron capture radiography for studying the biodistribution of tumor-seeking boron-containing compounds, Cancer Res. 47: 5451.PubMedGoogle Scholar
  7. Henderson, B.W., Waldow, S.M., Mang, T.S., Potter, W.R., Malone, P.B., and Dougherty, T.J., 1985, Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photo-dynamic therapy, Cancer Res. 45: 572.PubMedGoogle Scholar
  8. Kaczmarczyk, A., Messer, J.R., and Pierce, C.E., 1971, Rapid determination of boron in biological materials, Anal. Chem. 43: 271.PubMedCrossRefGoogle Scholar
  9. Kirsch, J.E., and Brownell, G.L., 1984, Improved methods of neutron-induced track etch autoradiography, in “Proceedings of the First International Symposium on Neutron Capture Therapy”, R.G. Fairchild and G.L. Brownell, eds., BNL Report 51730, Upton, N.Y.Google Scholar
  10. Oenbrink, G., JOrgenlimke, P., and Gabel, D., 1988, Accumulation of porphyrins in cells: Influence of hydrophobicity, aggregation and protein binding, Photochem. Photobiol., in the press.Google Scholar
  11. Winkelman, J. 1962, The distribution of tetraphenylporphinsulfonate in the tumor-bearing rat, Cancer Res. 22: 589.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Detlef Gabel
    • 1
  1. 1.Department of ChemistryUniversity of BremenBremenGermany

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