Survival Assays with a Boronated Porphyrin as Measured with Hamster V-79 Cells in Culture
On the basis of their weight, boron-carrying capacity and propensity for tumor, porphyrins would appear to be the ideal carrier-molecules for use in boron neutron therapy (BNCT). In the past, problems such as toxicity, solubility and/or lability of the boron tag precluded the use of porphyrins for BNCT. However, a newly-synthesized boronated porphyrin appears to have surmounted these problems and, in preliminary in vitro studies, SBK-II has demonstrated biological efficacy. Preliminary data will be presented here comparing SBK-II with the monomeric (BSH) and dimeric (BSSB) forms of the sulfhydryl boron hydride currently being considered for use in BNCT clinical trials in the United States.
KeywordsBoric Acid Neutron Irradiation Relative Biological Effectiveness Survival Assay Chinese Hamster Cell
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- 1.R. G. Fairchild, B. H. Laster, S. L. Commerford, P. S. Furcinitti, B. Sylvester, D. Gabel, E. Popenoe, and S. Foster, Proc. of Workshop on Photon Activation Therapy.Upton. April. 1985. Brookhaven National Lab. Report No. 51997, pp. 1–16 (1986).Google Scholar