A Carboranyl Porphyrin for Boron Neutron Capture Therapy of Brain Tumors
Many porphyrins are known to concentrate in tumor tissue both in vivo and in vitro, but the mechanisms of porphyrin-tumor affinity are unknown. A central theme of boron neutron capture therapy (BNCT) research is the search for boronated substances with high affinity for tumor. There is interest in the synthesis of boron-containing porphyrins and their evaluation for possible efficacy in BNCT. This study presents some modifications of a previously described methodl for synthesis of a particular nidocarboranyl porphyrin and some preliminary experimental indications of its potential usefulness for BNCT.
KeywordsAscitic Fluid Boron Concentration Boron Neutron Capture Therapy Brookhaven National Laboratory Total Porphyrin
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