Abstract
A satisfactory agent for boron neutron capture therapy (BNCT) must bind tumor cells in preference to normal cellular elements of the brain. However, it must also be delivered in sufficient concentration to the tumor cells by the bloodstream. The latter depends upon the degree of uptake or binding of the agent by blood cells or plasma proteins, the blood flow within the tumor, the permeability of the tumor vasculature to the particular boronated agent, and the distribution volumes of the agent within the tumor and adjacent brain tissue1,2.
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Keywords
- Brain Tumor
- Regional Blood Flow
- Malignant Brain Tumor
- Boron Neutron Capture Therapy
- Metastatic Brain Tumor
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References
J.D. Fenstermacher, Drug transfer across the blood-brain barrier, in: “Topic in pharmaceutical sciences,” D.D. Breimer and P. Speiser,eds.,Elsevier,Amsterdam (1983)
J. Fenstermacher and J. Gazendam, Intra-arterial infusions of drugs and hyperosmotic solutions as ways of enhancing CNS chemotherapy. Cancer Treat. Rep. 65 (Suppl. 2): 27 (1981)
R.G. Blasberg, T. Kobayashi, C.S. Patlak, M. Shinohara, M. Miyoaka, J.M. Rice, and W.R. Shapiro, Regional blood flow, capillary permeability, and glucose utilization in two brain tumor models: Preliminary observations and pharmacokinetic implications. Cancer Treat. Rep. 65 (Suppl. 2): 3 (1981)
R.G. Blasberg, W.R. Shapiro, P. Molnar, C.S. Patlak, and J.D. Fenstermacher, Local blood flow in Walker 256 metastatic brain tumors. J. Neuro-Oncol. 2: 195 (1984)
R.G. Blasberg, P. Molnar, M. Horowitz, P. Kornblith, R. Pleasants, and J. Fenstermacher. Regional blood flow in RT-9 brain tumors. J. Neurosurg. 58: 863 (1983)
R.G. Blasberg, T. Kobayashi, M. Horowitz, J.M. Rice, D. Groothuis, P. Molnar and J.D. Fenstermacher. Regional blood flow in ethylnitrosourea-induced brain tumors. Ann. Neurol. 14: 189 (1983)
Molnar, R.G. Blasberg, and D. Goothuis. Regional blood-to-tissue transport in avian sarcoma virus (ASV)-induced brain tumors. Neurology 33: 702 (1983)
R.G. Blasberg, J. Gazendam, W.R. Shapiro, M. Shinohara, C.S. Patlak, and J.D. Fenstermacher. Clinical implications of quantitative autoradiographic measurements of regional blood flow, capillary permeability and glucose utilization in a metastatic brain tumor model, in: “Treatment of Neoplastic Lesions of the Nervous System,” J. Holderbrand and D. Gangji, eds., Pergamon, New York (1982)
R.G. Blasberg, W.R. Shapiro, P. Molnar, C.S. Patlak, and J.D. Fenstermacher. Local blood-totissue transport in Walker 256 metastatic brain tumors. J. Neuro-Oncol. 2: 205 (1984)
R.G. Blasberg, T. Kobayashi, M. Horowitz, J.M. Rice, D. Groothuis, P. Molnar, and J.D. Fenstermacher. Regional blood-to-brain tissue transport in ethylnitrosourea-induced brain tumors. Ann. Neurol. 14: 202 (1983)
P. Molnar, R.G. Blasberg, M. Horowitz, B. Smith, and J. Fenstermacher. Regional blood-to-tissue transport in RT-9 brain tumors. J. Neurosurg. 58: 874 (1983)
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© 1989 Plenum Press, New York
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Tyson, G., Fenstermacher, J., Davis, R. (1989). Vascular Factors Affecting Drug Delivery to Brain Tumors. In: Fairchild, R.G., Bond, V.P., Woodhead, A.D., Vivirito, K. (eds) Clinical Aspects of Neutron Capture Therapy. Basic Life Sciences, vol 50. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5622-6_16
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