Vascular Factors Affecting Drug Delivery to Brain Tumors
A satisfactory agent for boron neutron capture therapy (BNCT) must bind tumor cells in preference to normal cellular elements of the brain. However, it must also be delivered in sufficient concentration to the tumor cells by the bloodstream. The latter depends upon the degree of uptake or binding of the agent by blood cells or plasma proteins, the blood flow within the tumor, the permeability of the tumor vasculature to the particular boronated agent, and the distribution volumes of the agent within the tumor and adjacent brain tissue1,2.
KeywordsBrain Tumor Regional Blood Flow Malignant Brain Tumor Boron Neutron Capture Therapy Metastatic Brain Tumor
Unable to display preview. Download preview PDF.
- 1.J.D. Fenstermacher, Drug transfer across the blood-brain barrier, in: “Topic in pharmaceutical sciences,” D.D. Breimer and P. Speiser,eds.,Elsevier,Amsterdam (1983)Google Scholar
- 2.J. Fenstermacher and J. Gazendam, Intra-arterial infusions of drugs and hyperosmotic solutions as ways of enhancing CNS chemotherapy. Cancer Treat. Rep. 65 (Suppl. 2): 27 (1981)Google Scholar
- 3.R.G. Blasberg, T. Kobayashi, C.S. Patlak, M. Shinohara, M. Miyoaka, J.M. Rice, and W.R. Shapiro, Regional blood flow, capillary permeability, and glucose utilization in two brain tumor models: Preliminary observations and pharmacokinetic implications. Cancer Treat. Rep. 65 (Suppl. 2): 3 (1981)Google Scholar
- 4.R.G. Blasberg, W.R. Shapiro, P. Molnar, C.S. Patlak, and J.D. Fenstermacher, Local blood flow in Walker 256 metastatic brain tumors. J. Neuro-Oncol. 2: 195 (1984)Google Scholar
- 8.R.G. Blasberg, J. Gazendam, W.R. Shapiro, M. Shinohara, C.S. Patlak, and J.D. Fenstermacher. Clinical implications of quantitative autoradiographic measurements of regional blood flow, capillary permeability and glucose utilization in a metastatic brain tumor model, in: “Treatment of Neoplastic Lesions of the Nervous System,” J. Holderbrand and D. Gangji, eds., Pergamon, New York (1982)Google Scholar
- 9.R.G. Blasberg, W.R. Shapiro, P. Molnar, C.S. Patlak, and J.D. Fenstermacher. Local blood-totissue transport in Walker 256 metastatic brain tumors. J. Neuro-Oncol. 2: 205 (1984)Google Scholar