Fractionation Considerations for Boron Neutron Capture Therapy: The Perspective of a Clinician
Fractionation is the cornerstone of modern megavoltage photon therapy. The sparsely ionizing nature of x-ray therapy seems to necessitate fractionation for successful sterilization of malignant tumors. However, high-LET, densely ionizing radiations such as neutrons or alpha particles are less dependent on fractionation for their success. In this context, I will weigh the advantages and disadvantages of fractionation for boron neutron capture therapy for malignant gliomas.