Delayed Effects of Neutron Irradiation on Central Nervous System Microvasculature in the Rat
Pathologic examination of a series of 14 patients with malignant gliomas treated with BNCT showed well demarcated zones of radiation damage characterized by coagulation necrosis. Beam attenuation was correlated with edema, loss of parenchymal elements, demyelination, leukocytosis, and peripheral gliosis. Vascular disturbances consisted of endothelial swelling, medial and adventitial proliferation, fibrin impregnation, frequent thrombosis, and perivascular inflammation. Radiation changes appeared to be acute and delayed. The outcome of the patients in this series was not significantly different from the natural course of the disease, even though two of the patients had no residual tumor detected at the time of autopsy. The intensity of the vascular changes raised a suspicion that boron may have sequestered in vessel walls, resulting in selectively high doses of radiation to these structures (Asbury et al., 1972), or that there may have been high blood concentrations of boron at the time of treatment. The potential limiting effects of a vascular ischemic reaction in Boron Neutron Capture Therapy (BNCT) prompted the following study to investigate the delayed response of microvascular structures in a rat model currently being used for pre-clinical investigations.
KeywordsCaudate Nucleus Basal Lamina Neutron Irradiation Boron Neutron Capture Therapy Spurr Resin
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