BNCT and Dose Fractionation

  • John L. RussellJr.
Part of the Basic Life Sciences book series (BLSC, volume 50)


Some portion of the radiation dose received by a patient during BNCT consists of primary and secondary gammas. The biological effect of that portion of the dose will depend upon the time history of the delivered dose. The well-known models for relating time-dose effects to clinical experience, principally those of Orton1 and Ellis2 are of questionable value in understanding dose effects in the time regime of a few hours, and for doses of less than tolerance. In order to examine the time-dose effect in the regime of interest to BNCT a simple phenomenological model was developed and normalized to the accepted body of clinical experience. The model has been applied to the question of fractionation of BNCT and the results are presented.


Continuous Radiation Tolerance Dose Dose Fractionation Time Regime Dose History 
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  1. 1.
    C. D. Orton, Time-dose factors (TDFs) in brachytherapy, Br. J. Radiol. 47: 603 (1974).PubMedCrossRefGoogle Scholar
  2. 2.
    F. Ellis, Fractionation in radiotherapy, in: “Modern Trends in Radiotherapy,” T. J. Deeley and C. A. P. Woods, eds., Vol. 1, Butterworth, London (1967).Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • John L. RussellJr.
    • 1
  1. 1.Theragenics CorporationAtlantaUSA

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