Dose Rate and Therapeutic Gain

  • R. G. Fairchild
Part of the Basic Life Sciences book series (BLSC, volume 50)


There is a consensus that previous difficulties encountered in U.S. clinical trials of NCT resulted from the use of inorganic compounds showing no tumor selectivity, and the use of thermal neutron beams which are known to have poor penetration in tissue (HVL ≈ 1.8 cm). Consequently, normal surface tissues were over-exposed, while viable tumor remained at depth. Since then, these problems have been largely circumvented through the development of epithermal neutron beams with better tissue penetration, and the synthesis of various boronated biomolecules which demonstrate tumor selectivity.


Neutron Beam Boron Neutron Capture Therapy Therapeutic Gain Effective Dose Rate Boron Hydride 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • R. G. Fairchild
    • 1
  1. 1.Medical DepartmentBrookhaven National LaboratoryUptonUSA

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