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The Effect of Phenylhydrazine on the Membrane Phospholipid Organization

  • A. Arduini
  • J. Dejulia
  • V. Damonti
  • G. Mancinelli
  • A. Di Bartolomeo
  • M. Belfiglio
  • M. De Cesare
  • A. Stern
Conference paper

Abstract

Phenylhydrazine (PH) represents an interesting probe in oxidative damage studies in human erythrocytes. We have recently demonstrated that spectrin, one of the most important cytoskeleton membrane proteins, was degraded after exposure of human red blood cells to PH. Because spectrin seems to be involved in the maintenance of phase-state asymmetry in the erythrocyte membrane, we decided to study the membrane phospholipid organization (MPO) in PH treated human red cells utilizing different methodological approaches.

Keywords

Fluorescence Polarization Lucifer Yellow Fluorescence Polarization Immunoassay Trinitrobenzene Sulfonic Acid Fluorescence Microscopic Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • A. Arduini
    • 1
  • J. Dejulia
    • 1
  • V. Damonti
    • 1
  • G. Mancinelli
    • 1
  • A. Di Bartolomeo
    • 1
  • M. Belfiglio
    • 1
  • M. De Cesare
    • 1
  • A. Stern
    • 2
  1. 1.Istituto di Scienze Biochimiche, Facolta di MedicinaUniversita degli Studi “G. D’Annunzio” ChietiItaly
  2. 2.Department of PharmacologyNew York UniversityUSA

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