Fluorescence Studies on Membranes from Human Skin Fibroblasts Deficient in Plasmalogens
Plasmalogens (1-0-alkenyl-2-acyl-glycerophospholipids) are important constituents of most animal cell membranes. In artificial membranes, they differ from the “common” diacyl glycerophospholipids with regard to physical properties and interaction with sterols and proteins. Nothing is known, however, about the impact of plasmalogens on the properties of biological membranes. In order to address this problem, we started a comparative fluorescence study on the membrane properties of cultured fibroblasts deficient in plasmalogens (from patients with the cerebro-hepato-renal “Zellweger-Syndrome”) and cells with a normal plasmalogen level (controls).
KeywordsMembrane Fluidity Fluorescence Anisotropy Artificial Membrane Ethanolamine Plasmalogens Choline Phospholipid
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