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Fluorescence Studies on Membranes from Human Skin Fibroblasts Deficient in Plasmalogens

  • A. Hermetter
  • B. Rainer
  • G. Schwabe
  • A. Roscher
  • F. Paltauf
Conference paper

Abstract

Plasmalogens (1-0-alkenyl-2-acyl-glycerophospholipids) are important constituents of most animal cell membranes. In artificial membranes, they differ from the “common” diacyl glycerophospholipids with regard to physical properties and interaction with sterols and proteins. Nothing is known, however, about the impact of plasmalogens on the properties of biological membranes. In order to address this problem, we started a comparative fluorescence study on the membrane properties of cultured fibroblasts deficient in plasmalogens (from patients with the cerebro-hepato-renal “Zellweger-Syndrome”) and cells with a normal plasmalogen level (controls).

Keywords

Membrane Fluidity Fluorescence Anisotropy Artificial Membrane Ethanolamine Plasmalogens Choline Phospholipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • A. Hermetter
    • 1
  • B. Rainer
    • 1
  • G. Schwabe
    • 1
  • A. Roscher
    • 1
  • F. Paltauf
    • 1
  1. 1.Department of BiochemistryTechnical University of GrazAustria

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