Conformational Flexibility of the Polypeptide Hormone Bombesin: Time Resolved and Static Fluorescence Studies
The three groups of peptides, the bombesins, sauvagine and the dermor-phins were first isolated from amphibian skin (Erspamer and Melchiorri, 1980a; Erspamer and Melchiorri, 1980b; Erspamer et al., 1980; Montecucchi et al., 1981; Montecucchi, 1981) and preceded the discovery of analogous peptides in mammalian tissues. Skin peptides have revealed interesting and unexpected actions both on the CNS and the endocrine system showing a wide range of activities. Their use in contributing to the understanding of the mechanisms underlying the central regulation of several visceral functions, the peripheral regulation of gut secretion and mobility, and the control of the release of hypophysary hormones is the basis for the ever growing interest in this group of peptides.
KeywordsAnisotropy Titration Lysine Polypeptide Arginine
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