Prediabetes pp 71-77 | Cite as

Cytoplasmic Islet Cell Autoantibodies: Prevalence and Pathognomic Significance

  • Helga Gleichmann
  • Gian Franco Bottazzo
  • Friedrich Arnold Gries
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


For many decades insulin-dependent diabetes mellitus (IDDM = Type I diabetes) has been regarded as a metabolic disorder with a typical acute clinical onset. In the past 15 years, however, there have been substantial changes in previously established concepts of the etiopathogenesis of Type I diabetes (1,2). Based on immunologic, genetic and epidemiologic studies it is apparent that the majority of patients with Type I diabetes have a long, clinically silent prediabetic period. This latency period, which can antedate clinically overt manifestation of insulin-deficiency for up to several years, is featured by the presence of various autoimmune phenomena (2,3). Currently chronic autoimmune reactions are widely believed to play a key role in the progressive destruction of the insulin-producing beta-cells of the Langerhans islets, although a direct autoimmune attack has still to be proved.


Islet Cell Antibody IDDM Patient Precision Score Juvenile Diabetes Mellitus Overt Manifestation 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Helga Gleichmann
    • 1
  • Gian Franco Bottazzo
    • 2
  • Friedrich Arnold Gries
    • 2
  1. 1.Clinical Department, Diabetes Research InstituteUniversity of DusseldorfFederal Republic of Germany
  2. 2.Department of Immunology, Arthur Stanley HouseThe Middlesex Hospital Medical SchoolLondonUK

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