Prediabetes pp 45-51 | Cite as

Insulin Autoantibodies in Pre-Diabetes

  • William J. Riley
  • Mark A. Atkinson
  • Noel K. MacLaren
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


Evidence that insulin dependent diabetes mellitus (IDD) is an autoimmune disease has accumulated since autoantibodies to cytoplasmic antigens (ICA)in the pancreatic islet cell were first described a decade ago (1). In addition, other autoantibodies reactive to cell surface antigens of islet cells (ICSA) have been identified using various methods and sources of islet tissue (2–3). The frequencies of these islet reactive antibodies are highest near the time of diagnosis of IDD and fall progressively thereafter. Recently, several reports have observed that ICA can also present years before the onset of clinical diabetes and may, therefore, serve as markers for the autoimmune destruction of beta cells (4–5).


Atrophic Gastritis Pernicious Anemia Insulin Binding Exogenous Insulin Islet Cell Antibody 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • William J. Riley
    • 1
  • Mark A. Atkinson
    • 1
  • Noel K. MacLaren
    • 1
  1. 1.Departments of Pathology and PediatricsUniversity Of Florida College of MedicineGainesvilleUSA

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