Prediabetes pp 397-402 | Cite as

The Incidence of Diabetes in BB Rats is Decreased Following Acute LCMV Infection

  • Thomas Dyrberg
  • Peter Schwimmbeck
  • Michael Oldstone
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


BB rats are a well studied animal model of insulin dependent diabetes mellitus (IDDM). About 59–90% of animals spontaneously develop IDDM between 60–140 days of age, characterized by weight loss, glycosuria, hyperglycemia, and mononuclear infiltrations of the islets of Langerhans (1). The pathogenesis is believed to be immune mediated as they show a number of immune abnormalities, including autoantibodies to islet cells, lymphocytic infiltration and injury to islets can be demonstrated before and during the onset of IDDM. The immune regulation is defective in the BB rats as indicated by reduced mixed lymphocyte reactions and reduced responsiveness to T-cell mitogens. Lymphopenia may accompany the course of disease but by itself it is not a prerequisite for development of IDDM. The immune pathogenesis can be passively transferred to non-diabetic animals by concanavalin A stimulated lymphocytes, and recently it has been shown that IDDM in BB rats can be prevented by treatment with monoclonal antibodies which recognize T-lymphocytes or natural killer cells (2)


Mixed Lymphocyte Reaction Lymphocytic Choriomeningitis Lymphocytic Choriomeningitis Virus LCMV Infection Spontaneous Autoimmune Diabetes 
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  1. 1.
    Marliss, E., A. Nakhooda, P. Poussier, and A. Sima, 1982, The diabetic syndrome of the “BB” Wistar rat: possible relevance to type I (insulin-dependent) diabetes in man. Diabetologia 22: 225–232.PubMedCrossRefGoogle Scholar
  2. 2.
    Like A.A., C.A. Biron, E.J. Weringer, K. Byman, E. Sroczynski and D.L. Guberski, 1986, Prevention of diabetes in Biobreeding/Worcester rats with monoclonal antibodies that recognize T. lymphocytes or natural killer cells. J Exp Med, 164: 1145–1159.PubMedCrossRefGoogle Scholar
  3. 3.
    McChesney, M., and M.B.A. Oldstone, 1987, Viruses perturb lymphocyte functions: selected principles characterizing virus-induced immunosuppression. Annu Rev Immunol 5:279–304.PubMedCrossRefGoogle Scholar
  4. 4.
    Ahmed, R., A. Salmi, L. Butler, J. Chiller, and M.B.A. Oldstone, 1984, Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. J Exp Med 160: 521–540.PubMedCrossRefGoogle Scholar
  5. 5.
    Doyle, M.V., and M.B.A. Oldstone, 1978, Interactions between viruses and lymphocytes. I. In vivo replication of lniiphocytic choriomeningitis virus in mononuclear cells during both chronic and acute viral infections. J Immunol 121: 1262–1269.PubMedGoogle Scholar
  6. 6.
    Like A.A., and A.A. Rossini, 1984, Spontaneous autoimmune diabetes mellitus in the Bio Breeding/Worcester rat. Surv Synth Pathol Res 3: 131.PubMedGoogle Scholar
  7. 7.
    Schwimmbeck, P.L., T. Dyrberg and M.B.A. Oldstone, 1988, Abrogation of diabetes in BB rats by acute virus infection: association of viral-lymphocyte interactions. J Immunol 140: 3394–3400.PubMedGoogle Scholar
  8. 8.
    Oldstone, M.B.A., 1988, Prevention of type I diabetes in NOD mice by virus infection. Science 239: 500–502.PubMedCrossRefGoogle Scholar
  9. 9.
    Tonietti, G., M.B.A. Oldstone, and F. Dixon, 1970, The effect of induced chronic viral infections on the immunologic diseases of New Zealand mice. J Exp Med 132: 89–109.PubMedCrossRefGoogle Scholar
  10. 10.
    Oldstone, M.B.A., and F. Dixon, 1972, Inhibition of antibodies to nuclear antigen and to DNA in New Zealand mice infected with lactate dehydrogenase virus. Science (Wash. DC) 175: 784–786.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Thomas Dyrberg
    • 1
  • Peter Schwimmbeck
    • 2
  • Michael Oldstone
    • 3
  1. 1.Hagedorn Research LaboratoryGentofteDenmark
  2. 2.University of DüsseldorfDusseldorfWest Germany
  3. 3.Scripps Clinic and Research FoundationLa JollaUSA

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