Prediabetes pp 387-395 | Cite as

Prevention of Diabetes in the BB Rat by Injection of Major Histocompatibility Complex- (MHC-) Compatible Bone Marrow Cells

  • Joanne Scott
  • Victor H. Engelhard
  • David C. Benjamin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


The emerging consensus that Type I diabetes mellitus has an autoimmune etiology has led to speculation that it could be prevented or cured by manipulation of the immune system. A concise understanding of the role of the immune system in the pathogenesis of Type I diabetes is crucial to devising preventive measures. Our understanding of the events that precede the onset of Type 1 diabetes comes mainly from the study of animal models. The availability of these models has prompted efforts to gain better understanding of the fundamental nature of autoimmune diseases in generl, and of type 1 diabetes in particular, through extensive studies of their immunologic abnormalities.


Bone Marrow Spleen Cell Bone Marrow Chimera Bone Marrow Recipient Neonatal Thymectomy 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Joanne Scott
    • 1
  • Victor H. Engelhard
    • 2
  • David C. Benjamin
    • 2
  1. 1.Departments of Pediatrics and PharmacologyUniversity of Virginia School of MedicineCharlottesvilleUSA
  2. 2.Department of MicrobiologyUniversity of Virginia School of Medicine CharlottesvilleVirginiaUSA

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