Prevention of Diabetes in the BB Rat by Injection of Major Histocompatibility Complex- (MHC-) Compatible Bone Marrow Cells
The emerging consensus that Type I diabetes mellitus has an autoimmune etiology has led to speculation that it could be prevented or cured by manipulation of the immune system. A concise understanding of the role of the immune system in the pathogenesis of Type I diabetes is crucial to devising preventive measures. Our understanding of the events that precede the onset of Type 1 diabetes comes mainly from the study of animal models. The availability of these models has prompted efforts to gain better understanding of the fundamental nature of autoimmune diseases in generl, and of type 1 diabetes in particular, through extensive studies of their immunologic abnormalities.
KeywordsBone Marrow Spleen Cell Bone Marrow Chimera Bone Marrow Recipient Neonatal Thymectomy
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