Regulatory T Cell Control of Autoimmune Destruction of Beta Cells In The BB Rat
Type I insulin-dependent diabetes mellitus (IDDM) in humans appears to be an autoimmune-mediated disease process that selectively destroys the pancreatic beta cells (1). Numerous lines of evidence support the concept of an autoiimnune pathogenesis of IDDM. A mononuclear cell infiltration of the islets of Langerhans (insulitis) is observed in diabetics, consisting predominately of Ia+ activated T cells and monocytes. Islet cell autoantibodies are readily detectable in the serum of people with IDDM, and lymphocytes from acutely diabetics children can kill human insulinoma cells in vitro. Futhermore, IDDM appears to have a genetic component that is strongly associated with the major histocompatibility complex, and patients with IDDM have a high incidence of other autoimmune disorders (1).
KeywordsMajor Histocompatibility Complex Beta Cell Islet Autoantibody Autoimmune Destruction Peripheral Lymphoid Tissue
Unable to display preview. Download preview PDF.
- Greiner, D.L., Mordes, J.P., Angelillo, M., Handler, E.S., Mojcik, C.F., Nakaittura, N. Rossini, A.A., 1988, Role of regulatory RT6+ T cells in the pathogenesis of diabetes mellitus in BioBreeding/Worcester (BB/Wor) rats. Frontiers in Diabetes Research: Lessons from Animal Diabetes II. Renold, A. & Shafrir, E., Eds., London, John Libbey & Co. In press.Google Scholar
- 6.Rossini, A.A., Mordes, J.P., Greiner, D.L., Nakano, N., Appel, M.C., Handler, E.S., 1986, Spleen cell transfusion in the Bio-Breeding/ Worcester rat: Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells. J. Clin. Invest. 77: 1399–1401.PubMedCrossRefGoogle Scholar
- Mordes, J.P., McKeever, U., Handler, E.S., Greiner, D.L., Burstein, D., Rossini, A.A., 1988, Immune modulation of autoimmune diabetes in the BB rat. Frontiers in Diabetes Research: Lessons from Animal Diabetes II. Renold, A. & Shafrir, E., Eds., London, John Libbey & Co. In press.Google Scholar
- Nakano, K., Mordes, J.P., Handler, E.S., Greiner, D.L., Rossini, A.A., 1988, The role of the host immune system in the BB/Wor rat: Predisposition to diabetes resides in the bone marrow. Diabetes. In press.Google Scholar