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Prediabetes pp 379-385 | Cite as

Regulatory T Cell Control of Autoimmune Destruction of Beta Cells In The BB Rat

  • Dale L. Greiner
  • Marianne Angelillo
  • John P. Mordes
  • Eugene S. Handler
  • Christopher F. Mojcik
  • Naoto Nakamura
  • Aldo A. Rossini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)

Abstract

Type I insulin-dependent diabetes mellitus (IDDM) in humans appears to be an autoimmune-mediated disease process that selectively destroys the pancreatic beta cells (1). Numerous lines of evidence support the concept of an autoiimnune pathogenesis of IDDM. A mononuclear cell infiltration of the islets of Langerhans (insulitis) is observed in diabetics, consisting predominately of Ia+ activated T cells and monocytes. Islet cell autoantibodies are readily detectable in the serum of people with IDDM, and lymphocytes from acutely diabetics children can kill human insulinoma cells in vitro. Futhermore, IDDM appears to have a genetic component that is strongly associated with the major histocompatibility complex, and patients with IDDM have a high incidence of other autoimmune disorders (1).

Keywords

Major Histocompatibility Complex Beta Cell Islet Autoantibody Autoimmune Destruction Peripheral Lymphoid Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Dale L. Greiner
    • 1
  • Marianne Angelillo
    • 1
  • John P. Mordes
    • 2
  • Eugene S. Handler
    • 2
  • Christopher F. Mojcik
    • 1
  • Naoto Nakamura
    • 2
  • Aldo A. Rossini
    • 2
  1. 1.Department of PathologyUniversity of Connecticut Health CenterFarmingtonUSA
  2. 2.Departnient of MedicineUniversity of Massachusetts Medical SchoolWorcesterUSA

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