Prevention of Diabetes-Related Retinal Microangiopathy with Aldose Reductase Inhibitors
One of the most significant breakthroughs in research on diabetes since the advent of insulin was the discovery, in animal models, that the polyol pathway involving aldose reductase is responsible for tissue complications similar to those occurring in diabetic patients (1). Under diabetic conditions polyol accumulates in cells from the activity of aldose reductase which would normally remain inactive. The accumulation of intracellular polyol and associated loss of myo-inositol somehow result in alternations in cell function and eventual cell death, though the mechanisms are not thoroughly understood and may vary from tissues to tissue.
KeywordsBasement Membrane Diabetic Retinopathy Aldose Reductase Mural Cell Aldose Reductase Inhibitor
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