Prediabetes pp 357-364 | Cite as

Immunomodulation of Pre-Diabetes in BB Rats for Prevention of the Disease

  • J. F. Markmann
  • A. Naji
  • C. F. Barker
  • K. L. Brayman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


The use of insulin therapy in the treatment of diabetes was naturally heralded as a cure for this otherwise lethal malady (1). It has now become apparent that, although insulin therapy avoids the acute morbidity and mortality associated with the disease, it allows those afflicted to develop a host of chronic debilitating complications. To eliminate such complications it seems likely that more refined treatment modalities and/or effective disease prevention strategies will be necessary, and that this will require further understanding the pathogenesis of insulin dependent diabetes mellitus (IDDM).


Tolerance Model Spontaneous Diabetes Neonatal Tolerance Prediabetic Period Wistar Furth 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. F. Markmann
    • 1
  • A. Naji
    • 1
  • C. F. Barker
    • 1
  • K. L. Brayman
    • 1
  1. 1.Department of SurgeryUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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