Some Characteristics of Chemically-Induced Beta-Cell Lesions as Possible Contributing Factors in Diabetes
It is generally accepted that the prediabetic state in IDDM is characterized by a progressive attack on the B cells, resulting in eventual B-cell death, and overt diabetes. The immune system, viruses or toxic chemicals in the environment may be involved. However, little is known how: chemical agents, possibly arising from these sources, are lethal to the B cell; these effects are propagated; and eventually how the target B cell can be protected from such chemical attacks.
KeywordsInsulin Secretion Beta Cell Phorbol Ester Immune Attack Beta Cell Replication
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- 2.Bolaffi, J.L., Nagamatsu, S., Harris, J., Grodsky, G.M.. 1987, Protection by thymidine, an inhibitor of polyadenosine diphosphate ribosylation, of streptozotocin inhibition of insulin secretion. Endocrinology§ 120: 2117. § Figure from this article reproduced here with permission of The Endocrine Society.PubMedCrossRefGoogle Scholar
- 3.Bolaffi, J.L., Nowlain, R.E., Cruz, L., Grodsky, G.M., 1986, Progressive damage of cultured pancreatic islets after single early exposure to streptozotocin. Diabetes§ 35: 1027. §Figure from this article reproduced here with permission of American Diabetes Association, Inc.PubMedCrossRefGoogle Scholar