Abstract
It is generally accepted that the prediabetic state in IDDM is characterized by a progressive attack on the B cells, resulting in eventual B-cell death, and overt diabetes. The immune system, viruses or toxic chemicals in the environment may be involved. However, little is known how: chemical agents, possibly arising from these sources, are lethal to the B cell; these effects are propagated; and eventually how the target B cell can be protected from such chemical attacks.
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© 1988 Plenum Press, New York
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Grodsky, G.M., Bolaffi, J.L. (1988). Some Characteristics of Chemically-Induced Beta-Cell Lesions as Possible Contributing Factors in Diabetes. In: Camerini-Davalos, R.A., Cole, H.S. (eds) Prediabetes. Advances in Experimental Medicine and Biology, vol 246. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5616-5_42
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DOI: https://doi.org/10.1007/978-1-4684-5616-5_42
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