Prediabetes pp 339-346 | Cite as

Some Characteristics of Chemically-Induced Beta-Cell Lesions as Possible Contributing Factors in Diabetes

  • Gerold M. Grodsky
  • Janice L. Bolaffi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


It is generally accepted that the prediabetic state in IDDM is characterized by a progressive attack on the B cells, resulting in eventual B-cell death, and overt diabetes. The immune system, viruses or toxic chemicals in the environment may be involved. However, little is known how: chemical agents, possibly arising from these sources, are lethal to the B cell; these effects are propagated; and eventually how the target B cell can be protected from such chemical attacks.


Insulin Secretion Beta Cell Phorbol Ester Immune Attack Beta Cell Replication 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Gerold M. Grodsky
    • 1
  • Janice L. Bolaffi
    • 1
  1. 1.Metabolic Research UnitUniversity of CaliforniaSan FranciscoUSA

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