Prediabetes pp 333-337 | Cite as

Kidney Disease in KK Mice: Effect Of Insulin

  • R. A. Camerini-Davalos
  • A. S. Reddi
  • H. Wehner
  • C. A. Velasco
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


We reported that improvement in glucose metabolism with prolonged oral therapy is associated with prevention of glomerulosclerosis and proteinuria in KK mice. However, it is not known whether short-term insulin treatment with improvement in glucose metabolism would similarly prevent the development and progression of glomerulosclerosis in these KK mice. We provide evidence that good glycemic control by early insulin therapy improves both glomerulosclerosis and proteinuria in KK mice.


Diabetic Nephropathy Oral Glucose Tolerance Test Mesangial Matrix Good Glycemic Control Silver Methenamine 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • R. A. Camerini-Davalos
    • 1
  • A. S. Reddi
    • 2
  • H. Wehner
    • 3
  • C. A. Velasco
    • 1
  1. 1.Department of Medicine, Metropolitan Hospital Research CenterNew York Medical CollegeNew YorkUSA
  2. 2.Department of MedicineUMDNJ-New Jersey Medical SchoolNewarkUSA
  3. 3.Institute of PathologyUniversity of FreibergWest Germany

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