Continuous Insulin Treatment in the Chinese Hamster a Review
Diabetes in the adult diabetic Chinese hamster is characterized by subnormal plasma and pancreatic insulin, impaired stimulated insulin secretion, and insulin resistance (1–3). In most regards this model resembles non-obese NIDDM reviewed in (2). Of particular interest is the observation that in young pre-diabetic animals, with little or no hyperglycemia, hyper-insulinemia is observed (4). Furthermore, perfused pancreata from 6–12 week animals respond normally to stimuli; impairment of insulin release is noted only by 17–21 weeks (1). Thus, there is a predictable onset of diabetes (to 95% in certain sublines).
KeywordsInsulin Resistance Insulin Release Diabetic Animal Insulin Infusion Urine Glucose
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