Prediabetes pp 329-332 | Cite as

Continuous Insulin Treatment in the Chinese Hamster a Review

  • Gerold M. Grodsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


Diabetes in the adult diabetic Chinese hamster is characterized by subnormal plasma and pancreatic insulin, impaired stimulated insulin secretion, and insulin resistance (1–3). In most regards this model resembles non-obese NIDDM reviewed in (2). Of particular interest is the observation that in young pre-diabetic animals, with little or no hyperglycemia, hyper-insulinemia is observed (4). Furthermore, perfused pancreata from 6–12 week animals respond normally to stimuli; impairment of insulin release is noted only by 17–21 weeks (1). Thus, there is a predictable onset of diabetes (to 95% in certain sublines).


Insulin Resistance Insulin Release Diabetic Animal Insulin Infusion Urine Glucose 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Gerold M. Grodsky
    • 1
  1. 1.Metabolic Research UnitUniversity of CaliforniaSan FranciscoUSA

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