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Prediabetes pp 329-332 | Cite as

Continuous Insulin Treatment in the Chinese Hamster a Review

  • Gerold M. Grodsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)

Abstract

Diabetes in the adult diabetic Chinese hamster is characterized by subnormal plasma and pancreatic insulin, impaired stimulated insulin secretion, and insulin resistance (1–3). In most regards this model resembles non-obese NIDDM reviewed in (2). Of particular interest is the observation that in young pre-diabetic animals, with little or no hyperglycemia, hyper-insulinemia is observed (4). Furthermore, perfused pancreata from 6–12 week animals respond normally to stimuli; impairment of insulin release is noted only by 17–21 weeks (1). Thus, there is a predictable onset of diabetes (to 95% in certain sublines).

Keywords

Insulin Resistance Insulin Release Diabetic Animal Insulin Infusion Urine Glucose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Frankel, B.J., Heidt, A.M., Gerritsen, G.C., Grodsky, G.M., 1984, Insulin, glucagon, and somatostatin release from the prediabetic Chinese hamster. Diabetologia 27: 387.PubMedCrossRefGoogle Scholar
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    Frankel, G.J., Schmid, F.G., Grodsky, G.M., 1979, Effect of continuous insulin infusion with an implantable seven-day minipump in the diabetic Chinese hamster. Endocrinology 104: 1532.PubMedCrossRefGoogle Scholar
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    Grodsky, G.M., Frankel, G.J., Gerich, J.E., Gerritsen, G.G., 1974, The diabetic Chinese hamster: in vitro insulin and glucagon release; the “chemical diabetic;” and the effect of diet on ketonuria. Diabetologia (Suppl.) 10: 521.Google Scholar
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    Gerritsen, G.C., Connel, M.A., Blanks, M.C., 1981, Effect of environmental factors including nutrition on genetically determined diabetes of Chinese hamsters. Proc. Nutr. Soc. 40: 237.PubMedCrossRefGoogle Scholar
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Gerold M. Grodsky
    • 1
  1. 1.Metabolic Research UnitUniversity of CaliforniaSan FranciscoUSA

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