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Prediabetes pp 29-31 | Cite as

Development of Diabetes in the Non-Obese NIDDM Rat (GK Rat)

  • Yoshio Goto
  • Ken-ichi Suzuki
  • Toshio Ono
  • Masayoshi Sasaki
  • Takayoshi Toyota
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)

Abstract

We produce spontaneously diabetic rats from normal rats by repeating the selective breeding using glucose intolerance as the selection index. The rats are called GK rats and now we have the 37th generation. In this paper, characteristic features, insulin secretion and the effect of obesity will be presented.

Keywords

Glucose Intolerance Nerve Conduction Velocity Selective Breeding Insulin Content Nerve Fiber Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Goto, Y., Kakizaki, M., Masaki, N., 1975, Spontaneous diabetes produced by selective breeding of normal Wistar rats. Proc Jap Acad 51: 80–85.Google Scholar
  2. 2.
    Goto, Y., Kakizaki, M., 1981, The spontaneous-diabetes rat: a model of noninsulin dependent diabetes mellitus. Proc Jap Acad 57,B: 381–384.CrossRefGoogle Scholar
  3. 3.
    Goto, Y., Kakizaki, M., Yagihashi, S., 1982, Neurological findings in spontaneously diabetic rats. Excerpta Medica ICS No. 581: 26–38.Google Scholar
  4. 4.
    Suzuki, K., Sasaki, M., Ono, T., Abe, S., Toyota, T., Goto, Y., 1987, Recent findings on spontaneously diabetic GK rat. Diabetic Animals, 1: 125–133.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Yoshio Goto
    • 1
  • Ken-ichi Suzuki
    • 1
  • Toshio Ono
    • 1
  • Masayoshi Sasaki
    • 1
  • Takayoshi Toyota
    • 1
  1. 1.Third Department of Internal MedicineTohoku University School of MedicineSendaiJapan

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