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Prediabetes pp 313-319 | Cite as

Effect of Gliclazide on Non-Insulin Dependent Diabetes Mellitus

  • B. J. Wajchenberg
  • A. T. M. Santomaruo
  • J. J. Cherem
  • D. A. C. Malerbi
  • A. Giurno Filho
  • A. C. Lerario
  • D. Giannella Neto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)

Abstract

The hyperglycemia of non-insulin dependent diabetes mellitus (NIDDM) has been attributed to both glucose overproduction by the liver and gluclose under-utilization by peripheral tissues caused by deficient insulin secretion and resistance to insulin action. There is recent evidence that the induction of insulin deficiency creates insulin resistance (1). Several mechanisms have been postulated for the chronic “hypoglycemic” effects of sulfonylurea therapy in NIDDM. In relation to gliclazide (GCZ), there are studies indicating an effect on insulin secretion (2,3,4) and an extra- pancreatic action related to potentiation of the bioeffects of insulin (5,6). In the present study we examined the effects of chronic GCZ therapy on basal insulin levels, glucose and non-glucose (arginine) stimulated insulin responses (Study I), hepatic glucose production rate, peripheral tissue sensitivity to insulin and on red blood cells (RBC) insulin binding (Study II).

Keywords

Fasting Plasma Glucose Insulin Binding NIDDM Patient Sulfonylurea Therapy Plasma Insulin Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • B. J. Wajchenberg
    • 1
  • A. T. M. Santomaruo
    • 1
  • J. J. Cherem
    • 1
  • D. A. C. Malerbi
    • 1
  • A. Giurno Filho
    • 1
  • A. C. Lerario
    • 1
  • D. Giannella Neto
    • 1
  1. 1.Diabetes Section, Endocrine Division and Laboratory of Medical Research (LIM n 25)Hospital das ClinicasSao PauloBrazil

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