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Prediabetes pp 305-312 | Cite as

Kidney Disease in KK Mice: Effect of Glipizide

  • A. S. Reddi
  • C. A. Velasco
  • M. Y. Khan
  • J. M. B. BloodworthJr
  • R. A. Camerini-Davalos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)

Abstract

We previously demonstrated that glomerulosclerosis and proteinuria can be prevented by control of blood glucose levels either by insulin or glyburide in genetically diabetic KK mice (1,2). Also, we demonstrated that poor control of glucose despite treatment with glyburide did not prevent glomerulosclerosis in a subset of KK mice (2). This reinforces the impact of glycemic control in the prevention of diabetic nephropathy. The purpose of the present study is two-fold: 1) to evaluate the efficacy of another second generation sulfonylurea compound, glipizide, in controlling blood glucose levels in KK mice; and 2) to investigate the relationship between glucose control and structural, biochemical and functional characteristics of kidney disease in KK mice.

Keywords

Diabetic Nephropathy Oral Glucose Tolerance Test Glomerular Basement Membrane Kidney Weight Kidney Size 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • A. S. Reddi
    • 1
  • C. A. Velasco
    • 2
  • M. Y. Khan
    • 1
  • J. M. B. BloodworthJr
    • 3
  • R. A. Camerini-Davalos
    • 3
  1. 1.Department of MedicineUMDNJ-New Jersey Medical SchoolNewarkUSA
  2. 2.Department of Medicine, Metropolitan Hospital Research CenterNew York Medical CollegeNew YorkUSA
  3. 3.Department of PathologyUniversity of Wisconsin Medical SchoolMadisonUSA

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