Kidney Disease in KK Mice: Effect of Glyburide
In previous publications (1,2) and in the present volume, we reported that the KK mouse represents an ideal animal model for the study of kidney disease in Type II diabetes. We report here the effect of early and late glyburide (a second generation oral hypoglycemic compound) treatment on glucose metabolism and its relationship to glomerulosclerosis in KK mice.
KeywordsOral Glucose Tolerance Test Blood Sugar Level Glyburide Treatment Swiss Albino Mouse Improve Glucose Tolerance
Unable to display preview. Download preview PDF.
- 1.Camerini-Davalos, R.A., Oppermann, W., Mittl, R., and Ehrenreich, T., Studies of vascular and other lesions in KK mice. Diabetologia 6: 324–329.Google Scholar
- 2.Reddi, A.S., Oppermann, W., Velasco, C.A., Strugat, L.H., and Camerini-Davalos, R.A., 1980, Diabetes mellitus in the KK mouse: Similarities and differences between genetic and other types of diabetes. In Secondary Diabetes: The spectrum of the diabetic syndromes, Podolsky, S. and Viswanathan, M., Eds., New York, Raven Press: 455–469.Google Scholar