Diabetogenicity of Various Protein Sources in the Diet of the Diabetes-Prone BB Rat
Insulin dependent diabetes mellitus (IDDM) has a wide geographic distribution ranging from 0.8/100,000 in Japan to 9 in Canada, 14.7 in the U.S.A. to 28.6 in Finland. As well, there is discordance in identical twins, and it has been suggested we are in the midst of an “epidemic” of IDDM which cannot be explained easily in terms of genetics alone (1). Other epidemiological data, as well as studies in animals, suggest environmental factors may be important in determining the expression of this presumed autoimmune: disease in genetically predisposed individuals. (2).
KeywordsPeripheral Blood Lymphocyte Protein Source Fish Meal Diabetes Incidence Wheat Gluten
Unable to display preview. Download preview PDF.
- 3.Scott, F. W., Daneman, D., Martin, J.M., 1988, Evidence for a critical role of diet in the development of insulin-dependent diabetes mellitus. Diabetes Res (In Press).Google Scholar
- 4.Scott, F. W., 1988, Dietary initiators and modifiers of BB rat diabetes: A summary and working hypothesis. In: Lessons from Animal Diabetes II, Shafrir, E. and Renold, A. E., Eds., John Libbey & Co., London.Google Scholar
- 6.Batsford, S., Schwerdtfeger, M. Rohrbach, R., Cambiaso, C., Kluthe, R., 1984, Synthetic amino acid diet prolongs survival in autoimmune murine disease. Clin Nephrol 21: 60–63.Google Scholar
- 8.Bieri, J.G., Stroewsand, G.S., Briggs, G.M., Phillips, R.W., Woodard, J.C., Knapka, J.J., 1977, Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J Nutrit 107: 1340–48.Google Scholar