Prediabetes and the Pathological Lesions of the Pancreas
In the insulin dependent diabetes (Type I) a specific histological lesion has been described by W. Gepts (1). The lymphocytic infiltration in the islet of Langerhans, known as insulitis, is associated with a progressive disappearance of the Beta cells. Electron microscopy studies in men and animals indicate that an early phase consists of the invasion of the islets by macrophages and a concommitant disruption of the plasma membrane specifically of the Beta cells. At a later stage, lymphocytic infiltration is observed possibly accompanied by polinnorphonuclear leucocytes and histiocytes. The progressive destruction of Beta cells is associated in some pancreas with occasional signs of Beta cell regeneration. The impending infiltration disappears when the Beta cells have vanished. The regeneration of the Beta cells seems not to be able to cope with their destruction (2).
KeywordsBeta Cell Lymphocytic Infiltration Beta Cell Mass Islet Cell Antibody Discordant Pair
Unable to display preview. Download preview PDF.
- 3.Betterle, C., Presotto, F., Pedini, B., Moro, L., Slack, R.S., Zanette, F., Zanchetta, R., 1987, Islet cell and insulin autoantibodies in organspecific autoimmune patients. Their behaviour and predictive value for the development of Type I (insulin dependent) diabetes mellitus. A 10- year follow-up study. Diabetologia 30: 292–297.PubMedCrossRefGoogle Scholar
- 5.Clark, A., Copper, G.J.S., Lewis, C.E., Morris, J.F., Willis, A.C., Reid, K.B.M., Turner, R.C., 1987, Islet amyloid formed from diabetes- associated peptide may be pathogenic in Type II diabetes. The Lancet, August 1st Issue: 231–234.Google Scholar
- 6.Hoet, J. J., and Remade, C., 1987, Pancreatic Islets, Organization of the pancreatic Islets with Special References to Diabetes, Endocrinology 1987, Eds. L. J. DeGroot et al., Grune & Stratton, New York, San Francisco and London.Google Scholar