Prediabetes pp 241-253 | Cite as

Genetic and Humoral Markers in IDDM Patients and their Families

  • Maximino Ruiz
  • Felix E. Puchulu
  • Alejo Florin Christensen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


The association between some HLA and insulin-dependent diabetes was demonstrated by Nerup et al1 when they observed a high prevalence of HLA B8 B15 in this type of diabetes. Afterwards, several authors2 demonstrated that there are a linkage disequilibrium of the HLA B8 and B15 and the HLA DR3 and DR4, and that these are the principal genetic markers.


Beta Cell Insulin Dependent Diabetes Islet Cell Antibody Congenital Rubella Syndrome Proinsulin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Nerup, J., Platz, P., Andersen, O.O., Christy, M., Lyngsol, J., Poulsen, J.E., Ryder, L.P., Nielsen, L.S., Thomsen, M., Svejgaard, A., 1974, HLA antigens and diabetes mellitus. Lancet 2: 864–866.PubMedCrossRefGoogle Scholar
  2. 2.
    Cudworth, A.G., Woodrow, J.C., 1975, Evidence for HLA-linked clues in juvenile diabetes mellitus. Br Med J 3: 133–135.PubMedCrossRefGoogle Scholar
  3. 3.
    Bottazzo, G.F., Florin-Christensen, A., Doniach, D., 1974, Islet I cell antibodies in daibetes mellitus with autoimmune polyendocrine deficiency. Lancet 2: 1279–1283.PubMedCrossRefGoogle Scholar
  4. 4.
    Bottazzo, G.F., Pujol-Borrell, R. and Gale, E., 1985, Etiology of diabetes: the role of autoimmune mechanisms In The Diabetes Annual 1 by Alberti, K.G.M.M. and Krall, L.P. Elsevier, Amsterdam: 16.Google Scholar
  5. 5.
    Morales, V.H., Garcia Morteo, O., Salvioli, J.E., Cedola, N., De Marco R., 1983, HLA and insulin dependent diabetes. Analysis in Argentina in Diabetes Mellitus by Salvioli, J. and De Marco, R., Eds., Panamericana Bs. As.: 329.Google Scholar
  6. 6.
    Verruno, L., Haas, E., Raimondi, E., 1983, Frequency of antigens, genes and association between loci A and B in Argentina- XV Meeting of the Argentine Society of Clincial Research-Mar del Plata-Argentina.Google Scholar
  7. 7.
    Barbosa, J., Chavers, B., Dunsworth, T., Michael, A., 1982, Islet cell antibodies and histocompatibility antigens in insulin-dependent diabetics and their first degree relatives. Diabetes 31: 585–588.PubMedGoogle Scholar
  8. 8.
    MacDonald, M., Famuyiwa, O., Nwabuebo, I., Bella, A., Junaid, T.A., Marrari, M., Duquesnoy, R.J., 1986, HLA - Or association in black Type I diabetics in Nigeria. Diabetes 35: 583–589.PubMedCrossRefGoogle Scholar
  9. 9.
    Pirosky, I., Cantora, M., Vellard, J., Braunstein, J., Alessandria, J., 1983, Genetic analysis in a Toba Indian population. Frequency of HLA-DR Medicina (Buenos Aires) 43: 281–284.Google Scholar
  10. 10.
    Serrano Rios M., Regueiro, J.R., Severino, R. et al. 1983, HLA antigens in insulin-dependent and non insulin-dependent Spanish diabetic patients. Diabetes Metabol 9: 116–120.Google Scholar
  11. 11.
    Terasaki, P.I., McClelland, J.D., 1964, Microdroplet assay of human serum cytotoxins. Nature 204: 998.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Maximino Ruiz
    • 1
  • Felix E. Puchulu
    • 1
  • Alejo Florin Christensen
    • 1
  1. 1.Fundacion Argentina de Diabetes y Enfermedades Metabolicas (FADEM) Seccion Diabetologia of Hospital de Clinicas “Jose de San Martin ”Centro de Educacion Medica e Investigaciones Clinicas (CEMIC)Argentina

Personalised recommendations