Prediabetes pp 235-239 | Cite as

Can the High Risk of Type I Diabetes in Finland be Explained by Familial Aggregation and by HLA Haplotype Distribution?

  • Eva Wolf
  • Jaakko Tuomilehto
  • Raisa Luonamaa
  • The Study Group on Childhood Diabetes in Finland
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


Finland is the country which has the highest incidence of Type I (insulin dependent) diabetes in the world. The age-adjusted annual incidence in 1977 to 1984 was 30 per 100,000 in the age group 0–15 years (1). Finland is also one of the countries in the world where the incidence of Type I diabetes is rapidly increasing. The latest data from 1986 to 1987 indicate that the incidence is now about 40 per 100,000 which means about 350 new cases per year.


Familial Aggregation Diabetic Child Multiplex Family Locus Antigen Disease Susceptibility Gene 


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  1. 1.
    Akerblom, H.K., Reunanen, A., 1985, The epidemiology of insulin- dependent diabetes mellitus (IDDM) in Finland and in Northern Europe. Diabetes Care 8:Suppl. 1: 10–16.PubMedGoogle Scholar
  2. 2.
    Crumpton, M.J, 1987, HLA in medicine. Br Med Bull, 43: 1–240.Google Scholar
  3. 3.
    Walker, A., Cudworth, A.G., 1980, Type 1 (insulin dependent) diabetic multiplex families: Mode of genetic transmission. Diabetes 29: 1036–1039.PubMedCrossRefGoogle Scholar
  4. 4.
    Wakisaka, A., Aizawa, M., Matsura, N. et al., 1976, HLA and juvenile diabetes mellitus in the Japanese. Lancet 2: 970.PubMedCrossRefGoogle Scholar
  5. 5.
    Wolf, E., Tuomilehto, J., Cepaitis, Z., et al, (in preparation), A2, Cwl, Bw56, DR4 - a new haplotype increased in Type 1 diabetes in Finland.Google Scholar
  6. 6.
    Bentsson, B.O., Thompson, G., 1981, Measuring the strength of associations between HLA antigens and diseases. Tissue Antigen 18: 356–363.CrossRefGoogle Scholar
  7. 7.
    Wolf, E., Spencer, K.M., Cudworth, A.G., 1983, The genetic susceptibility to Type 1 (insulin dependent) diabetes: Analysis of the DR association. Diabetologia 24: 224–230.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Eva Wolf
  • Jaakko Tuomilehto
  • Raisa Luonamaa
  • The Study Group on Childhood Diabetes in Finland

There are no affiliations available

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