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Prediabetes pp 221-227 | Cite as

Children at High Risk of Diabetes Mellitus: New York Studies of Families with Diabetes and of Children with Congenital Rubella Syndrome

  • Robert C. McEvoy
  • Barbara Fedun
  • Louis Z. Cooper
  • Nancy M. Thomas
  • Santiago Rodriguez De Cordoba
  • Pablo Rubinstein
  • Fredda Ginsberg-Fellner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)

Abstract

The frequency of Type I, or insulin-dependent mellitus (IDDM) in the general population is approximately 1 in 600 individuals. By contrast, in families where one child has IDDM, the likelihood that another child will develop IDDM is about 100 times higher. This population, at high risk for the development of IDDM, seemed an ideal group in which to identify some of the factors which might precede the development of clinically apparent IDDM. IDDM is clearly a multifactorial disease. The existence of a gene or genes predisposing to diabetes and mapping within or very near the HLA locus on chromosome six has been suggested by several different investigators. In addition, environmental agents also appear to be needed to “trigger” the predisposition towards overt disease since concordance for monozygotic twins is estimated at only approximately 30%. Convincing evidence has accumulated over the last several years that the mechanism of the expression of the genetic susceptibility is an autoimmune destruction of the pancreatic beta cells.

Keywords

Islet Cell Rubella Virus Islet Cell Antibody Congenital Rubella Syndrome Insulin Autoantibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Robert C. McEvoy
    • 1
    • 2
  • Barbara Fedun
    • 3
  • Louis Z. Cooper
    • 3
  • Nancy M. Thomas
    • 2
  • Santiago Rodriguez De Cordoba
    • 4
  • Pablo Rubinstein
    • 4
  • Fredda Ginsberg-Fellner
    • 1
  1. 1.Department of PediatricsMount Sinai School of Medicine of the City University of New YorkUSA
  2. 2.Department of AnatomyMount Sinai School of Medicine of the City University of New YorkUSA
  3. 3.Developmental Disabilities Unit, Department of PediatricsSt. Luke’s Roosevelt Medical CenterUSA
  4. 4.Laboratory of ImmunogeneticsLindsley F. Kimbell Research Institute New York Blood CenterUSA

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