Prediabetes pp 209-214 | Cite as

Iselt-Cell and Insulin Autoantibodies in First-Degree Relatives of Type I Diabetics: A 5-Year Follow-Up Study in a Swiss Population

  • G. A. Spinas
  • L. Matter
  • T. Wilkin
  • O. Staffelbach
  • W. Berger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


It is widely accepted that autoimmune mechanisms are involved in the pathogenesis of type I (insulin-dependent, IDDM) diabetes mellitus. (1)Islet cell antibodies (ICA) reacting with antigens in the cytoplasma, or on the surface of islet-cells (ICSA), or against a 64 kD human islet-cell protein, as well as insulin autoantibodies (lAA) are present years before the onset of clinical diabetes. They probably serve as serologic markers of ongoing beta-cell destruction in predisposed individuals. In monozygotic twins initially discordant for type I diabetes, loss of beta-cell function has been shown to be temporarily associated with the presence of ICA (2). Several studies in discordant monozygotic twins or first-degree relatives of type I diabetics revealed that ICA-positive relatives are more likely to develop overt diabetes than are the ICA-negative (3). Moreover, the presence of both ICA and lAA in these individuals confers an even higher risk of progression to IDDM (1)


Islet Cell Antibody Insulin Autoantibody Pancreatic Specimen Discordant Monozygotic Twin Diabetic Proband 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • G. A. Spinas
    • 1
  • L. Matter
    • 2
  • T. Wilkin
    • 3
  • O. Staffelbach
    • 1
  • W. Berger
    • 1
  1. 1.Department of Internal MedicineUniversity Hospital of BasleSwitzerland
  2. 2.Clinical ImmunologyKantonsspitalSt. GallenSwitzerland
  3. 3.General HospitalSouthhamptonGreat Britain

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