Prediabetes pp 185-192 | Cite as

Antecedent Events for Non-Insulin Dependent Diabetes Mellitus

  • Peter H. Bennett
  • Clifton Bogardus
  • William C. Knowler
  • Stephen Lillioja
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


During the past decade there has been a proliferation of knowledge concerning non-insulin dependent diabetes. International acceptance of a classification of diabetes has contributed to this development in that non-insulin dependent diabetes (NIDDM) was clearly separated from insulin-dependent diabetes (IDDM), and the term impaired glucose tolerance (IGT) was introduced to describe a category of subjects who had glucose tolerance which was above the limits seen in normal healthy young adults, but which fell below the levels considered diagnostic of NIDDM (1). The diagnostic criteria for NIDDM were also reconsidered, first by the National Diabetes Data Group (NDDG) and later by the World Health Organization (WHO). This resulted in internationally accepted criteria for the diagnosis of diabetes.


Insulin Resistance Glucose Tolerance Insulin Level Impaired Glucose Tolerance Normal Glucose Tolerance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    World Health Organization, Geneva, 1985, Report of a Study Group: Diabetes Mellitus. World Health Organization Technical Report Series 727.Google Scholar
  2. 2.
    Barnett, A.H., Eff, C., Leslie, R.D.G., Pyke, D.A., 1981, Diabetes in identical twins: a study of 200 pairs. Diabetologia 25: 13–17.Google Scholar
  3. 3.
    Serjeantson, S.W., Owerbach, D., Zimmet, P., Nerup, J., Thoma, K., 1983, Genetics of Diabetes in Nauru: effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism. Diabetologia 25: 13–17.PubMedCrossRefGoogle Scholar
  4. 4.
    Stern, M.P., Ferrell, R.E., Rosenthal, M., Haffner, S.M., Hazuda, H.P., 1986, Association between NIDDM, Rh blood group and haptoglobin phen- otype: results from the San Antonio heart study. Diabetes 35: 387–391.PubMedCrossRefGoogle Scholar
  5. 5.
    Williams, R.C., Knowler, W.C., Butler, W.J., Pettitt, D.J., Lisse, J.R., Bennett, P.H., Mann, D.L., Johnson, A.H., Terasaki, P.I., 1981, HLA- A2 and type 2 (insulin independent) diabetes mellitus in Pima Indians: an association of allele frequency with age. Diabetologia 21: 460–463.PubMedCrossRefGoogle Scholar
  6. 6.
    Yamashita, T.S., Mackay, W., Rushforth, N.B., Bennett, P.H., Houser, H., 1984, Pedigree annlyses of non-insulin dependent diabetes in the Pima Indians suggest dominant mode of inheritance. Am J Hum Genet 36: 183S.Google Scholar
  7. 7.
    Reaven, G., Miller, R, 1968, Study of the relationship between glucose and insulin responses to an oral glucose load in man. Diabetes 17: 560–569.PubMedGoogle Scholar
  8. 8.
    Savage, P.J., Dippe, S.E., Bennett, P.H., Görden, P., Roth, J., Rushforth N.B., Miller, M., 1975, Hyperinsulinemia and hypoinsulinemia. Insulin responses to oral carbohydrate over a wide spectrum of glucose tolerance. Diabetes 24: 362–368.PubMedCrossRefGoogle Scholar
  9. 9.
    Bogardus, C., Lillioja, S., Howard, B.V., Reaven, G., Mott, D., 1984. Relationship between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J Clin Invest 74: 1238–1246.PubMedCrossRefGoogle Scholar
  10. 10.
    Groop, L., Miettinen, A., Groop, P-H., Meri, S., Koskimies, S., Bottazzo, G.F., 1988, Organ specific autoimmunity and HLA-DR antigens as markers for B cell destruction in patients with type II diabetes. Diabetes 37: 99–103.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Peter H. Bennett
    • 1
  • Clifton Bogardus
    • 1
  • William C. Knowler
    • 1
  • Stephen Lillioja
    • 1
  1. 1.Arizona Epidemiology and Clinical Research BranchNational Institutes of Health, National Institute of Arthritis Diabetes and Digestive and Kidney Diseases PhoenixUSA

Personalised recommendations