Low Insulin Response: A Marker Of Prediabetes
It is generally accepted that genetic factors play a decisive role in the development of non-insulin dependent diabetes (NIDDM). Accordingly, the manifest disease develops gradually from a genetically determined initial stage, prediabetes, over a stage characterized by a decrease in glucose tolerance only. This process might be slow or rapid, possibly dependent on the type and ‘weight’ of the genetic trait as well as on factors precipitating the disease.
KeywordsGlucose Tolerance Insulin Release Insulin Response Plasma Insulin Response Hyperglycemic Clamp
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- 1.Cerasi, E., Luft, R., 1967, The plasma insulin response to glucose infusion in healthy subjects and in diabetes mellitus. Acta Endocrinol (Copenh) 55: 278–304.Google Scholar
- 5.De Fronzo, R.A., Tobin, J.D., Andres, R., 1979, Glucose clamp technique: A method for quantifying insulin secretion and resistance. AM J Physiol 237: E214-E223.Google Scholar
- 6.Cerasi, E., 1975, Potentiation of insulin release by glucose in man. III. Normal recognition of glucose as a potentiator in subjects with low insulin response and in mild diabetes. Acta Endocrinol (Copenh) 79: 511–534.Google Scholar
- 7.Efendic S., Cerasi, E., Elander, I., 1980, Studies on low insulin responders. Acta Endocrinol (Copenh) 90: 1–32.Google Scholar
- 10.Gerasi, E., Fick, G., Rudemo, M., 1974, A mathematical model for the glucose induced insulin release in man. Eur J Glin Invest 4: 267–278.Google Scholar