Prediabetes pp 147-158 | Cite as

Sequence of Changes in KK Mouse Nephropathy

  • Herbert Wehner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)


The KK mouse is suitable for investigations of diabetic kidney changes (1) because it develops spontaneous diabetes mellitus with a genetic prediabetic phase. In addition, it develops the known vascular and neurogenic lesions which are comparable to those in human diabetics. It survives without therapy. Long-term observations are hence possible without interfering side effects of medication.


Proximal Tubule Diabetic Animal NMRI Mouse Glomerular Cell Papillary Necrosis 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Herbert Wehner
    • 1
  1. 1.Institute of PathologyGeneral HospitalWest Germany

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