Advertisement

Prediabetes pp 147-158 | Cite as

Sequence of Changes in KK Mouse Nephropathy

  • Herbert Wehner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 246)

Abstract

The KK mouse is suitable for investigations of diabetic kidney changes (1) because it develops spontaneous diabetes mellitus with a genetic prediabetic phase. In addition, it develops the known vascular and neurogenic lesions which are comparable to those in human diabetics. It survives without therapy. Long-term observations are hence possible without interfering side effects of medication.

Keywords

Proximal Tubule Diabetic Animal NMRI Mouse Glomerular Cell Papillary Necrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Camerini-Davalos, R.A., Reddi, A.S., Velasco, C.A., Oppermann, W., Wehner, H., Bloodworth, J.M.B., 1979, Microangiopathy in genetic prediabetes. Front Matrix Biol 7: 281–295.Google Scholar
  2. 2.
    Wehner, H., Hohn, D., Faix-Schade, U., Huber, H., Walzer, P, 1972, Glomerular changes in mice with spontaneous hereditary diabetes. Lab Invest 27: 331–340.PubMedGoogle Scholar
  3. 3.
    Volkmann, H.P., Wehner, H., 1986, Renal vessel changes in diabetic KK mice. Virchows Archiv (Pathol Anat) 409: 669–678.CrossRefGoogle Scholar
  4. 4.
    Kondo, K., Nozawa, K., Tomita, T., Ezaki, K, 1957, Inbred strains resulting from Japanese mice. Bull Exp Anim 6: 107–112.Google Scholar
  5. 5.
    Treser, G., Oppermann, W., Ehrenreich, T., Lange, K., Levine, R., Camerini-Davalos, R.A., 1968, Glomerular lesions in a strain of genetically diabetic mice. Proc Soc Exp Biol Med. 129: 820–823.PubMedGoogle Scholar
  6. 6.
    Wehner, H., Wagner, H., Podmaniczky, A., Heidbrink, V., Kiessling, B., 1978, Influence of short-term insulin therapy on th mesangial structure in young KK-mice. Nephron 22: 460–472.PubMedCrossRefGoogle Scholar
  7. 7.
    Wehner, H., König, I., 1982, Immunological transmission of glomerulosclerotic changes in KK-mice with spontaneous diabetes. 1. Transplantation of spleen cells. Virchows Archiv (Pathol Anat) 396: 61–71.CrossRefGoogle Scholar
  8. 8.
    Wehner, H., 1983, Kidney morphometry, 1983, In J.P.A. Baak and J. Gort: Manual of morphometry in diagnostic pathology. Springer, Heidelberg: 124–126, 174–175.Google Scholar
  9. 9.
    Roth, S.I., Conaway, H.H., Sanders, L.L., Casali, R.E., Boyd, A.E., 1980, Spontaneous diabetes mellitus in the New Zealand white rabbit. Preliminary morphologic characterization. Lab Invest 42: 571–579.PubMedGoogle Scholar
  10. 10.
    Cohen, A.J., McGill, P.D., Rossetti, R.G., Gubersi, D.L., Like, A.A., 1987, Glomerulopathy in spontaneously diabetic rat. Impact of glycemic control. Diabetes 36: 944–951.PubMedCrossRefGoogle Scholar
  11. 11.
    Oppermann, W., Ehrenreich, T., Patel, D., Espinoza, T., Camerini-Davalos, R.A., 1973, Related factors in the progression of microangiopathy in KK mice. In R.A. Camerini-Davalos and H. Cole, Eds., Early Diabetes, Adv Metab Dis; Suppl. 2: 281–290.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Herbert Wehner
    • 1
  1. 1.Institute of PathologyGeneral HospitalWest Germany

Personalised recommendations